Amyloidosis and Kidney Disease

Kidney Health Care - David Mangusan Jr., PTRP

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Dialysis-related amyloidosis (DRA) is common in patients, especially older adults, who have been on dialysis for more than 5 years. DRA develops when proteins in the blood deposit in bones, joints, and tendons. This can cause pain, stiffness, and fluid build-up in joints. Amyloid is the term used for abnormal depositions of proteins in tissues, and the disease process is called amyloidosis. Amyloid deposits may cause abnormal tears in ligaments and tendons.

According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), about half of people with DRA also develop a condition called carpal tunnel syndrome. It results from the unusual build-up of proteins in the wrists. Symptoms may include numbness or tingling sensation in the fingers and hands.

Unfortunately, there is no cure for DRA. Treating the complications, however, is beneficial, such as correcting the torn ligament or tendon and treating carpal tunnel syndrome. Successful kidney transplant may also stop dialysis-related amyloidosis from progressing.

References:

National Kidney and Urologic Diseases Informations Clearinghouse. Amyloidosis and Kidney Disease. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD. NIH Publication No. 06–4694, May 2006

National Kidney and Urologic Diseases Informations Clearinghouse. Anemia in Kidney Disease and Dialysis. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD. NIH Publication No. 05–4619, January 2005

National Kidney and Urologic Diseases Informations Clearinghouse. Renal Osteodystrophy. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD. NIH Publication No. 06–4630, January 2005


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